Nebraska 1854, when three women are driven insane on the edges of the American frontier, the task of delivering them back east falls to a pious spinster named Mary Bee Cuddy. The daunting challenge of driving a wagon loaded with madwomen four hundred miles compels her to employ a partner- a drifting low-life who goes by the name of ‘George Briggs’. Together, the unlikely pair head out across the prairie with their freakish cargo, re-traversing the harsh, untamed Nebraska Territories in a journey marked by stark beauty, constant threat, and psychological peril. Their destination is a Church in Iowa where a minister’s wife waits to relieve them of the lost souls in their care. But before they can cross back into civilization, their mission will exact a brutal toll - one that speaks to every backward tragedy and unsung act of heroism buried in the foundations of the American West.